TRUVADA for PrEP was studied in 2 separate clinical trials.
The first study followed adult
During the studies, all participants were told to use safer sex practices, including condoms. They also received monthly HIV testing and counseling. In the end, it was determined that TRUVADA for PrEP, used together with safer sex practices, helped reduce the chances of HIV infection in both groups that were studied compared to those taking a placebo (sugar pill).
Clinical studies showed that TRUVADA for PrEP works better when taken every day as directed.
After the initial studies were completed and the results were known, researchers conducted further analysis and looked at a sample of people who were assigned to take TRUVADA in the studies. They wanted to know if people who had TRUVADA in their body were better protected against HIV than those who did not.
In both studies, people with TRUVADA in their body* were less likely to get HIV. But keep in mind that this kind of analysis, called a "post-hoc analysis," should be interpreted with caution because it was not one of the original goals of either study.
Men who have sex with men and transgender women who have sex with men:
- Number of people who were assigned to take TRUVADA: 1,251
- Number of people who took a placebo (sugar pill): 1,248
Couples (male/female) where one partner has HIV and the other does not:
- Number of people who were assigned to take TRUVADA: 1,583
- Number of people who took a placebo (sugar pill): 1,586
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