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Combination Therapy: HAART

HIV reproduces at a rapid rate in the body, producing both perfect copies of itself and copies containing errors (mutations). Some of these viral mutations allow the HIV to resist the effects of a certain anti-HIV drug (called "drug resistance"), while remaining sensitive to other drugs used in a regimen. In some cases, one mutation will cause resistance to an entire class of HIV medications (called "cross resistance").

This is where HIV combination therapy, or HAART (Highly Active Antiretroviral Therapy), comes in. The usual HAART regimen combines three or more different drugs from different classes, such as two nucleoside reverse transcriptase inhibitors (NRTIs) and a protease inhibitor (PI), two NRTIs and a non-nucleoside reverse transcriptase inhibitor (NNRTI), or other combinations.


Combination drugs like TRUVADA combine two or more different drugs into one pill. Today, there is a wide selection of med combinations available including several once a day meds and regimens.

DHHS
Adapted from DHHS Guidelines, December 1, 2009. Please see the DHHS Guidelines for additional important information.

†NNRTI = Non-nucleoside reverse transcriptase inhibitor
‡NRTI = Nucleoside reverse transcriptase inhibitor
§PI = Protease inhibitor
‖INSTI = Integrase strand transfer inhibitor

Using three or more anti-HIV drugs (antiretrovirals) from different classes in combination allows them to work together to keep HIV levels down. Doctors and scientists have found that HAART can help control HIV and in many cases the viral load can become so low that HIV may not be detected in the blood. This is called "undetectable viral load."

Because every patient is unique, you should talk to your healthcare provider to learn more about which HAART combination may work best for you.

Which HIV Med Is Most Prescribed by Doctors?

Next: If HAART can work so well, then why does treatment failure happen?

Patients should read the Patient Information, including "What is the most important information I should know about TRUVADA?". It is important that you discuss your treatment options and any questions that you may have with your healthcare provider.

Please read the Full Prescribing Information for TRUVADA, EMTRIVA, and VIREAD, including Boxed WARNINGS.

Please read the Full Prescribing Information for TRUVADA, ATRIPLA, EMTRIVA, and VIREAD, including Boxed WARNINGS.

*Synovate Healthcare Data; U.S. HIV Monitor, Q3, 2009.